Math 865

 

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Course Description: Click here for details in a PDF file

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Course Syllabus: Click here for details in a PDF file

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Course: Mathematical Modeling of Biological Processes

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References: (1) Models of Cellular Regulation by Baltazar Aguda and Avner Friedman

bulletHandout: Lecture Notes
bulletOffice Hours: Friedman: by appointment; Kao: WF 10:30-11:30am @ JE340D
bulletGrading: HW(60%),final project and oral presentation(40%)
bullet Policy: Late Homework and project will be no credit.
bulletTentative Schedule: updated regularly

 

MWF Jennings Hall 050
Mar 28

Chemical Kinetics

Mass action law

 

Mar 30

Michaelis-Menten and Hill type kinetics

 

Apr 1

Computation:

Euler's method: Consistency, Stability, Convergence

 

Apr 4

Basic ODE thoery

existence

uniqueness by successive iterations

examples

Apr 6

Stability of steady state for one ODE

Phase portraits in the plane

Nullclines and Bistability

Apr 8

Computation:

forward and backward Euler's method

code: test_euler.m

code: test_euler2.m

Apr 11

Epidemiological models

SIR model

SIER model

 

Apr 13

Chemostats and Competing Populations

 

Apr 15

Computation:

solve roots of nonlinear systems

Matlab built-in function: fzero, fsolve, meshgrid, contour, gradient, quiver

 

Apr 18

Computation:

Numerical methods for solving eigenvalue problems

Apr 20

Bifurcation

Apr 22

Computation:

Bifurcation diagram

Apr 25

Hopf Bifurcation

Apr 27

Singular Perturbation

Neuronal Oscillation

Apr 29

Computation:

Bistability and hystereris

Hopf bifurcation

Singular perturbation

code: main_potential_eqn.m

code: potential_eqn.m

code: main_FitzhughNagumo.m

code: FitzhughNagumo_eqn.m

May 2

Hyperbolic systems

May 4

Neurofilaments Transport in Axon

May 6

Computation:

Simulation for hyperbolic equations

code: main_Upwind_LF.m

code: flux.m

code: exact1.m

code: bd1.m

code: IC1.m

 

May 9

Diffusion Equations

May 11

Wound Healing

May 13

HW: Problem 11.4

Computation:

Simulation for diffusion equations

Matlab pdepe help

pdex1.m

pdex4.m

May 16

Cancer

May 18

Cancer therapy

May 20

HW: 12.2

Computation:

Numerical simulation for wound healing

main_woundhealing.m

flux1_wound.m

May 23

Project I (Nianpeng Li, Moussa Doumbia)

Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making by Andrew Yates, robin Callard, Jaroslav Stark, Journal of Theoretical Biology, 231 (2004), p.181-196

Models of Cellular Regulation by Baltazar D. Aguda and Avner Friedman, Oxford Graduate Texts<, p.127-133/p>

May 25

Project II (Oyita Udiani)

A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction by Helen Moore and Natasha K. Li

Leukocytes. James Keener, James Sneyd. Mathematical Physiology. Vol II: Systems Physiology, Chapter 16, 495-507.

May 27

HW: 14.2, 14.3

Computation:

Cancer therapy simulation

CancerTherapy.m

tridiagSolve.m

May 30

Memorial Day: no class

Jun 1

Project III (Leah Campbell)

Transformed epithelial cells and fibroblasts/myofibroblasts interaction in breast tumor: a mathematical model and experiments by Yangjin Kim, Julie Wallace, Fu Li, Michael Ostrowski, and Avner Friedman, Journal of Mathematical Biology, 61 (2010), p.401-421

Jun 3

Project IV (Kyle Frank)

A mathematical analysis of the dynamics of prion proliferation by Meredith L. Greer, Laurent Pujo-Menjouet, Glenn F. Webb, Journal of Theoretical Biology, 242, 3, (2006), p.598-606

Project VII

Jun 7

(Jun 7 Tuesday: Jennings hall 050 , 9:30am -11:18am)

Project V (Laine Noble)

A mathematical model of tumor-immune evasion and siRNA treatment. J.C. Arciero, T.L. Jackson, and D.E. Kirschner. Discrete and Continuous Dynamical Systems-Series B, Vol 4, No. 1, Feb 2004, 39-58

Project VI (Noah Brostoff)

Essential mathematical Biology by Nicholas F. Britton, Chapter 5.6,Traveling Waves Solutions of General Reaction-diffusion Equations, p.164-173